Melanotan II
Melanogenesis and pigmentation research
Melanotan II is a synthetic analogue of alpha-melanocyte-stimulating hormone (alpha-MSH). It is primarily researched for its ability to stimulate melanogenesis — the production of melanin pigment in the skin. Additional research areas include appetite suppression and libido enhancement.
Research Benefits
How It Works
Melanotan II binds to melanocortin receptors (MC1R-MC5R), with primary activity at MC1R which stimulates melanocytes to produce melanin. This increases skin pigmentation independent of UV exposure, though UV enhances the effect. Cross-reactivity with MC4R contributes to appetite and libido effects.
Quick Reference — Melanotan II
10 mg vial
2 mL bacteriostatic water
5 mg/mL
0.25–1 mg
Daily during loading (1–2 weeks), then 2–3× per week maintenance
SC injection
Refrigerate; use within 30 days
Requires bacteriostatic water for reconstitution — available in our store. Start at 0.25 mg to assess tolerance. Nausea common initially. Facial flushing, spontaneous erections at higher doses. Use with UV exposure for best tan.
For research purposes only. Not for human consumption. Always consult qualified professionals.
Pairs well with
Melanotan II + GHK-Cu creates a comprehensive skin enhancement protocol — pigmentation plus collagen renewal. PT-141 shares melanocortin pathway synergy, and GLOW adds peptide-blend skin rejuvenation.
Questions about Melanotan II?
Our team responds within 24 hours. Reach out for bulk pricing, stacking advice, or technical questions.